In the last decade, there is a great interest in analytical miniaturized systems on microchips, and on chip integrated systems for different chemical processes like mixing, reactions and detection are on rapid progress.
The advantage of miniaturized integrated systems include less sample volume and reagent consumption, more effective reaction because of the large ratio of surface-to-volume and lower cost. It also permits a rapid and efficient mixing as well as the recording of continuous IR spectra. These benefits lead the microchip technology to the various applications like flow control, chemical analysis, biomedical diagnostics, drug discovery, inkjet printers, biochemical assays, genetic analysis, drug screening, electrochromatography.
Antithyroid drug measurement in microfluidic chip-PTLMDetermination of MMI Methimazole (1-methyl-2-mercaptoimidazole) (MMI) using glass microfluidic chip-photo thermal lens microscopy (MFC-PTLM) in human serum and pharmaceutical samples. Both MMI and gold nanoparticles (GNPs) solution were introduced at the same flow rate (200 μL/min) to the microchannels by two microfluidic syringe pumps VIT-FIT.
Protein conformation states studied using microfluidic mixerCommercial Fourier-transform infrared (FTIR) spectrometer was coupled to a microfluidic mixer to allow the on-line monitoring of protein conformation under varying conditions. Two VIT-FIT programmable microfluidic syringe pumps were used to deliver the protein and NaOH solutions to microfluidic mixer with two inlets, at slow flow rates (10 arb. units).
Bio cell manipulation using microfluidic cell rotatorThe orientation of the Zebrafish egg in the integrated cell processor was controlled by changing the flow rate in the microchannel using the micro syringe pump VIT-FIT which has the function of infusion and withdrawal. The flow in the microchannels and at the microhole was precisely controlled with microsyringes.
Low voltage DC electroporation on a microfluidic chipElectro Permeation of human cells was accomplished with a low dc input voltage in a novel microfluidic system. Polyelectrolytic salt bridges are constructed on a microfluidic chip for safe and efficient gene transfection. Cells were delivered into the microchannel by VIT-FIT syringe pump at a flow rate range of 1.6 to 8.5 μL/min.
Flow control in microfluidic / lab-on-chip applications
Microfluidic applications demand accurate control and measurement of small fluid flows and volumes within the microchannels. Precise and tunable flow rates are crucial in microfluidic applications involving droplets, cell manipulation, chemical and biomolecular sensing, and sample processing.